Endocannabinoid System Overactivity in Obesity

CB1 receptor overactivation: In obesity, CB1 (cannabinoid receptor type 1) tends to be overstimulated. This increases appetite, enhances the rewarding effects of food, promotes fat storage, and reduces energy expenditure. Elevated endocannabinoids: Molecules like anandamide (AEA) and 2-AG are often found in higher levels in obese individuals. Peripheral effects: Beyond the brain, CB1 activation in the liver promotes lipogenesis (fat